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Literature DB >> 10047524

Amorphous no longer: the centrosome comes into focus.

Abstract

Recent genetic and biochemical studies have provided new insights into the molecular basis of centrosome-mediated microtubule nucleation. In addition, molecules and mechanisms involved in microtubule severing and stabilization at the centrosome, assembly of proteins onto centrosomes and regulation of centrosome duplication and separation are being defined. Characterization of centrosome function, together with studies implicating centrosomes in tumorigenesis and demonstrating that centrosomes are highly organized, are beginning to bring into focus an organelle once viewed as an 'amorphous cloud'.

Mesh：

Substances：
Tubulin

Year: 1999 PMID： 10047524 DOI： 10.1016/s0955-0674(99)80015-5

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

Keyword Cloud
Cited

33 in total

1. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle.

Authors: E Freed; K R Lacey; P Huie; S A Lyapina; R J Deshaies; T Stearns; P K Jackson
Journal: Genes Dev Date: 1999-09-01 Impact factor: 11.361

2. Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes.

Authors: A Young; J B Dictenberg; A Purohit; R Tuft; S J Doxsey
Journal: Mol Biol Cell Date: 2000-06 Impact factor: 4.138

Review 3. Cell cycle regulation of the microtubular cytoskeleton.

Authors: M Vantard; R Cowling; C Delichère
Journal: Plant Mol Biol Date: 2000-08 Impact factor: 4.076

4. Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.

Authors: C L Lemos; P Sampaio; H Maiato; M Costa; L V Omel'yanchuk; V Liberal; C E Sunkel
Journal: EMBO J Date: 2000-07-17 Impact factor: 11.598

5. Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.

Authors: Maria Kraakman-van der Zwet; Wilhelmina J I Overkamp; Rebecca E E van Lange; Jeroen Essers; Annemarie van Duijn-Goedhart; Ingrid Wiggers; Srividya Swaminathan; Paul P W van Buul; Abdellatif Errami; Raoul T L Tan; Nicolaas G J Jaspers; Shyam K Sharan; Roland Kanaar; Malgorzata Z Zdzienicka
Journal: Mol Cell Biol Date: 2002-01 Impact factor: 4.272

6. Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes.

Authors: Y Nakagawa; Y Yamane; T Okanoue; S Tsukita; S Tsukita
Journal: Mol Biol Cell Date: 2001-06 Impact factor: 4.138

Amorphous no longer: the centrosome comes into focus.

1. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle.

2. Cytoplasmic dynein-mediated assembly of pericentrin and gamma tubulin onto centrosomes.

Review 3. Cell cycle regulation of the microtubular cytoskeleton.

4. Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.

5. Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.

6. Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes.

7. Centrosome maturation: measurement of microtubule nucleation throughout the cell cycle by using GFP-tagged EB1.

8. The centrosome: a multifaceted cellular weapon against chromosome instability.

9. Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function.

10. Toxoplasma gondii actively remodels the microtubule network in host cells.