| Literature DB >> 1004687 |
Abstract
The effect of steroid contraceptive drugs (SCDs) on the concentration of dopamine (DA) in the striatum was studied in mice and rats. Mestranol was combined with each one of the three progestins, lynestrenol, norethindrone and norethynodrel. Treatments were given daily for 1, 4 or 30 days; animals were sacrificed 1 or 18 h after the last administration. In all groups, with the exception of the animals sacrificed 1 h after an acute treatment, striatal DA was significantly lower than in controls.Entities:
Keywords: Amines; Animals, Laboratory; Biology; Catecholamines--analysis; Central Nervous System; Central Nervous System Effects; Clinical Research; Contraception; Contraceptive Agents, Estrogen--side effects; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--side effects; Family Planning; Ingredients And Chemicals; Lynestrenol--side effects; Mestranol--side effects; Norethindrone--side effects; Norethynodrel--side effects; Oral Contraceptives; Oral Contraceptives, Combined; Organic Chemicals; Physiology; Research Methodology
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Year: 1976 PMID： 1004687 DOI： 10.1159/000122513
Source DB: PubMed Journal: Neuroendocrinology ISSN： 0028-3835 Impact factor: 4.914