Literature DB >> 1004643

Blood flow in intact and constricted coronary arteries under the influence of ouabain.

G Raberger, W Schütz, M Zimpfer.   

Abstract

The effects of ouabain on intact and experimentally constricted coronary arteries were investigated in anaesthetized, thoracotomized dogs. Ouabain decreased the blood flow in the intact artery without changing the flow per beat values and increased flow in the constricted artery. Since ouabain decreased left ventricular enddiastolic pressure, it is proposed that the drug-induced augmentation of flow in the constricted artery is related to an elevation of driving pressure to the endocardial layers of the myocardium which are supplied by the constricted artery.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 1004643     DOI： 10.1007/bf00509772

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  7 in total

1.  Proceedings: Further studies on the neutralization of glycosine-induced contractures of coronary smooth muscle by Ca-antagonistic compounds (verapamil, D 600, prenylamine, nifedipine, fendiline or nitrites).

Authors:  A Fleckenstein; G Fleckenstein-Grün
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

2.  Strophanthin-G on coronary sinus outflow.

Authors:  T R SHERROD
Journal:  J Pharmacol Exp Ther       Date:  1952-04       Impact factor: 4.030

3.  Effect of ouabain on the coronary circulation and other circulatory functions in intact anesthetized dogs.

Authors:  R G PAGE; E L FOLTZ; W F SHELDON; H WENDEL
Journal:  J Pharmacol Exp Ther       Date:  1951-01       Impact factor: 4.030

4.  Proceedings: Augmentation of coronary smooth muscle tone and sensitization to Ca by cardiac glycosides.

Authors:  G Grün; U Weder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

5.  [Correlations between the final systolic ventricular volume per weight unit (ESV-100 g), the potential functions of arterial pressure (P) and the ventricular pressure increase velocity (dp-dt max ) resp].

Authors:  H J Bretschneider; J Martel; G Hellige; I Hensel; D Kettler
Journal:  Verh Dtsch Ges Kreislaufforsch       Date:  1972

6.  [Hemodynamic determinants of myocardial oxygen-need].

Authors:  H J Bretschneider
Journal:  Arzneimittelforschung       Date:  1971-10

7.  Effects of a digitalis glycoside on coronary and systemic dynamics in conscious dogs.

Authors:  S F Vatner; C B Higgins; D Franklin; E Braunwald
Journal:  Circ Res       Date:  1971-04       Impact factor: 17.367
  7 in total
  2 in total

1.  Haemodynamic and coronary actions of ouabain during coronary infusion.

Authors:  M Zimpfer; W Schütz; G Raberger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-08       Impact factor: 3.000

2.  Effect of ouabain on O2 supply/demand in normal and ischemic heart.

Authors:  E Buchweitz; J Bottalico; H R Weiss
Journal:  Basic Res Cardiol       Date:  1982 Sep-Oct       Impact factor: 17.165
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.