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Literature DB >> 1004641

Evidence for stimulation of 5-HT receptors in canine saphenous arteries by ergotamine.

Abstract

Changes in tension of spiral strips from dog saphenous arteries were monitored isometrically. Dose-response curves for noradrenaline, 5-HT and ergotamine were established without and after a 30 min incubation with phentolamine or pizotifen. Phentolamine was about 15 times more potent in antagonizing responses to noradrenaline (pA2 value=7.4) than those to 5-HT (pA2 value=6.2) but it was nearly equipotent in antagonizing responses to ergotamine (pA2 value=6.5) and those to 5-HT. Pizotifen was about 500 times less potent in antagonizing noradrenaline effects than 5-HT but again nearly equipotent when tested against ergotamine and 5-HT. It is suggested that in canine saphenous arteries the stimulant activity of ergotamine is mediated mainly through 5-HT receptors.

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Year: 1976 PMID： 1004641 DOI： 10.1007/bf00509770

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

8 in total

1. Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

Authors: J M VAN ROSSUM
Journal: Arch Int Pharmacodyn Ther Date: 1963

5 in total

Evidence for stimulation of 5-HT receptors in canine saphenous arteries by ergotamine.

1. Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

2. pA, a new scale for the measurement of drug antagonism.

3. Responsiveness of isolated canine cerebral and peripheral arteries to ergotamine.

4. Studies on the mechanism of the venoconstrictor activity of ergotamine on isolated canine saphenous veins.

5. Proceedings: Further studies on the mode of action of ergotamine on canine vein strips.

6. Enhanced prostaglandin synthesis contributes to the venoconstrictor activity of ergotamine.

7. Some quantitative uses of drug antagonists.

8. Investigations on the mode of action of ergotamine in the isolated femoral vein of the dog.

Review 1. Clinical pharmacology, physiology and pathophysiology of superficial veins--2.

2. Regional differences in the responsiveness of isolated arteries from cattle, dog and man.

3. Supersensitivity of atherosclerotic rabbit aorta to ergonovine. Mediation by a serotonergic mechanism.

4. Influence of pizotifen and ergotamine on the venoconstrictor effect of 5-hydroxytryptamine and noradrenaline in man.

5. Nitroglycerin for ergotism. Experimental studies in vitro and in migraine patients and treatment of an overt case.