Literature DB >> 1003558

Screening of cytotoxic drugs for residual bone marrow damage.

K J Trainor, A A Morley.   

Abstract

Several cytotoxic drugs were tested for their ability to produce permanent residual damage to the bone marrow. A short course of the drug was given to BALB/c female mice, and the numbers of various types of bone marrow cells were determined at least two months later. Evidence of residual damage was found after administration of busulfan and 1,3-bis(chloroethyl)-1-nitrosourea, but not after administration of cyclophosphamide, 5-fluorouracil, 6-mercaptopurine, methotrexate, or vinblastine.

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Year:  1976        PMID： 1003558     DOI： 10.1093/jnci/57.6.1237

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  7 in total

1.  Further development of a model of chronic bone marrow aplasia in the busulphan-treated mouse.

Authors:  John A Turton; William R Sones; Charles M Andrews; Andrew M Pilling; Thomas C Williams; Gemma Molyneux; Sian Rizzo; Edward C Gordon-Smith; Frances M Gibson
Journal:  Int J Exp Pathol       Date:  2006-02       Impact factor: 1.925

2.  The haemotoxicity of mitomycin in a repeat dose study in the female CD-1 mouse.

Authors:  Gemma Molyneux; Frances M Gibson; Edward C Gordon-Smith; Andrew M Pilling; Kai Chiu Liu; Sian Rizzo; Susan Sulsh; John A Turton
Journal:  Int J Exp Pathol       Date:  2005-12       Impact factor: 1.925

3.  A cellular analysis of long-term haematopoietic damage in mice after repeated treatment with cyclophosphamide.

Authors:  G Molineux; C Xu; J Hendry; N G Testa
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

4.  Tolerance of hemopoiesis for repeated cytotoxic drug therapy.

Authors:  H P Lohrmann
Journal:  Blut       Date:  1979-10

5.  A comparative study of therapeutic activity, myelotoxicity and DNA damage in the bone marrow of mice after cyclophosphamide and ASTA Z 7557 (INN mafosfamide).

Authors:  M R Berger; P Bedford; W J Zeller; M Kaufmann
Journal:  Invest New Drugs       Date:  1984       Impact factor: 3.850

6.  5-Fluorouracil treatment after irradiation impairs recovery of bone marrow functions.

Authors:  K H von Wangenheim; H P Peterson; E P Cronkite; L E Feinendegen
Journal:  Radiat Environ Biophys       Date:  1987       Impact factor: 1.925

7.  Primitive Sca-1 Positive Bone Marrow HSC in Mouse Model of Aplastic Anemia: A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy.

Authors:  Sumanta Chatterjee; Pratima Basak; Prosun Das; Madhurima Das; Jacintha Archana Pereira; Ranjan Kumar Dutta; Malay Chaklader; Samaresh Chaudhuri; Sujata Law
Journal:  Stem Cells Int       Date:  2009-10-28       Impact factor: 5.443
  7 in total

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