| Literature DB >> 1003531 |
S J Meischen, G R Gale, L M Lake, C J Frangakis, M G Rosenblum, E M Walker, L M Atkins, A B Smith.
Abstract
The antitumor activity of 46 cis-amineplatinum congeners was evaluated against L1210 leukemia in (C57BL/L X DBA/2)F1 mice. Several compounds in this series significantly prolonged the life-spans of mice with the leukemia. During the selection of the compound that yielded optimal activity [dichloro(1,2-diaminocyclohexane)platinum], the chlorides were substituted with various organic and inorganic anions. The aqueous solubility was greatly increased with retention of significant antileukemic activity. Most of the active compounds were synergistic with cyclophosphamide, and cure rates up to 80% were obtained with certain combinations.Entities:
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Year: 1976 PMID： 1003531 DOI： 10.1093/jnci/57.4.841
Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506