| Literature DB >> 1003411 |
R K Razdan, H C Dalzell, P Herlihy, J F Howes.
Abstract
Two delta8-THC derivatives, 4a and 4b, with functionalized side chains were synthesized. Treatment of (+)-trans-p-mentha-2,8-dien-1-ol with the resorcinal 2b followed by removal of the dithiol group with HgO--BF3-Et2O gave the aldehyde 3b. A Wittig reaction of dimethyl (2-oxoheptyl)phosphate with 3b furnished 4a, which was reduced to 4b. Compounds 4a and 4b showed potent cannabinoid-like activity in mice.Entities:
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Year: 1976 PMID： 1003411 DOI： 10.1021/jm00233a014
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446