Literature DB >> 100340

Possible explanation for interictal-ictal transition: evolution of epileptiform activity in hippocampal slice by chloride depletion.

N Ogata.   

Abstract

In thin hippocampal slices, paroxysmal epileptiform discharge was generated in high potassium medium. Removal of chloride from the high potassium medium caused explosive potentiation of the paroxysmal discharge and emergence of clonic relapsing discharges. Evolution of the paroxysm to regenerative seizure was attributed to the reduction of inhibitory postsynaptic potentials.

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Year:  1978        PMID： 100340     DOI： 10.1007/bf01915331

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Ionic mechanisms of the depolarization shift in thin hippocampal slices.

Authors:  N Ogata
Journal:  Exp Neurol       Date:  1975-01       Impact factor: 5.330

2.  LOCATION OF POSTSYNAPTIC INHIBITORY SYNAPSES ON HIPPOCAMPAL PYRAMIDS.

Authors:  P ANDERSEN; J C ECCLES; Y LOYNING
Journal:  J Neurophysiol       Date:  1964-07       Impact factor: 2.714

3.  Mechanisms of the stereotyped high-frequency burst in hippocampal pyramidal neurons in vitro.

Authors:  N Ogata
Journal:  Brain Res       Date:  1976-02-20       Impact factor: 3.252

4.  Mode of activation of pyramidal neurons by mossy fiber stimulation in thin hippocampal slices in vitro.

Authors:  N Ogata; S Ueno
Journal:  Exp Neurol       Date:  1976-11       Impact factor: 5.330

5.  The correlation between extracellular potassium concentration and hippocampal epileptic activity in vitro.

Authors:  N Ogata; N Hori; N Katsuda
Journal:  Brain Res       Date:  1976-07-09       Impact factor: 3.252

6.  Changes in extracellular potassium activity during neocortical propagated seizures.

Authors:  G W Sypert; A A Ward
Journal:  Exp Neurol       Date:  1974-10       Impact factor: 5.330

7.  Penicillin-induced interictal discharges from the cat hippocampus. II. Mechanisms underlying origin and restriction.

Authors:  M Dichter; W A Spencer
Journal:  J Neurophysiol       Date:  1969-09       Impact factor: 2.714

8.  Silent cells during interictal discharges and seizures in hippocampal penicillin foci. Evidence for the role of extracellular K+ in the transition from the interictal state to seizures.

Authors:  M A Dichter; C J Herman; M Selzer
Journal:  Brain Res       Date:  1972-12-24       Impact factor: 3.252

9.  The role of extracellular potassium in hippocampal epilepsy.

Authors:  R S Fisher; T A Pedley; W J Moody; D A Prince
Journal:  Arch Neurol       Date:  1976-02

10.  Electrical activities in thin sections from the mammalian brain maintained in chemically-defined media in vitro.

Authors:  C Yamamoto; H McIlwain
Journal:  J Neurochem       Date:  1966-12       Impact factor: 5.372
  10 in total
  3 in total

1.  Electrophysiology of mammalian hypothalamic and interpeduncular neurons in vitro.

Authors:  N Ogata
Journal:  Experientia       Date:  1979-09-15

2.  Hyperpolarizing potentials in guinea pig hippocampal CA3 neurons.

Authors:  W D Knowles; J H Schneiderman; H V Wheal; C E Stafstrom; P A Schwartzkroin
Journal:  Cell Mol Neurobiol       Date:  1984-09       Impact factor: 5.046

3.  Influence of ionic disturbances produced by gastric washing on cortical spreading depression.

Authors:  R C Guedes; R J do Carmo
Journal:  Exp Brain Res       Date:  1980       Impact factor: 1.972
  3 in total

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