Literature DB >> 1003109

Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids.

J Hamilton, J D Vassalli, E Reich.   

Abstract

Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.

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Year:  1976        PMID: 1003109      PMCID: PMC2190481          DOI: 10.1084/jem.144.6.1689

Source DB:  PubMed          Journal:  J Exp Med        ISSN: 0022-1007            Impact factor:   14.307


  8 in total

1.  Asbestosis associated with bronchogenic carcinoma.

Authors:  R STOLL; R BASS; A A ANGRIST
Journal:  AMA Arch Intern Med       Date:  1951-12

2.  Asbestos cancer: past and future hazards.

Authors:  J C Gilson
Journal:  Proc R Soc Med       Date:  1973-04

3.  Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes.

Authors:  P Davies; A C Allison; J Ackerman; A Butterfield; S Williams
Journal:  Nature       Date:  1974-10-04       Impact factor: 49.962

4.  Radiological diagnosis of crocidolite induced pleural mesotheliomata in the rat.

Authors:  M S McLachlan; J C Wagner
Journal:  Br J Exp Pathol       Date:  1974-04

5.  Macrophage plasminogen activator: modulation of enzyme production by anti-inflammatory steroids, mitotic inhibitors, and cyclic nucleotides.

Authors:  J D Vassalli; J Hamilton; E Reich
Journal:  Cell       Date:  1976-06       Impact factor: 41.582

6.  Induction of macrophage plasminogen activator by endotoxin stimulation and phagocytosis: evidence for a two-stage process.

Authors:  S Gordon; J C Unkeless; Z A Cohn
Journal:  J Exp Med       Date:  1974-10-01       Impact factor: 14.307

7.  Secretion of plasminogen activator by stimulated macrophages.

Authors:  J C Unkeless; S Gordon; E Reich
Journal:  J Exp Med       Date:  1974-04-01       Impact factor: 14.307

8.  Lysosomes in lymphoid tissue. I. The measurement of hydrolytic activities in whole homogenates.

Authors:  W E Bowers; J T Finkenstaedt; C de Duve
Journal:  J Cell Biol       Date:  1967-02       Impact factor: 10.539

  8 in total
  24 in total

1.  Acute injury and regeneration of the mesothelium in response to asbestos fibers.

Authors:  P A Moalli; J L MacDonald; L A Goodglick; A B Kane
Journal:  Am J Pathol       Date:  1987-09       Impact factor: 4.307

2.  The selective release of lysosomal acid hydrolases from mouse peritoneal macrophages by stimuli of chronic inflammation.

Authors:  H U Schorlemmer; P Davies; W Hylton; M Gugig; A C Allison
Journal:  Br J Exp Pathol       Date:  1977-06

3.  Effect of retinoic acid on asbestos induced plasminogen activator activity of peritoneal macrophages.

Authors:  D Lison; B Knoops; R Lauwerys
Journal:  Br J Ind Med       Date:  1989-07

4.  Oxidant production by control and inflammatory bronchoalveolar leukocyte populations treated with mineral dusts in vitro.

Authors:  K Donaldson; J Slight; R E Bolton
Journal:  Inflammation       Date:  1988-06       Impact factor: 4.092

5.  Early biochemical reactions in the lung of sheep exposed to asbestos: evidence for cyclic AMP accumulation in bronchoalveolar lavage fluids.

Authors:  I Lemaire; P Sirois; M Rola-Pleszczynski; S Massé; R Bégin
Journal:  Lung       Date:  1981       Impact factor: 2.584

6.  Role of alveolar macrophage plasminogen activator in the acute pulmonary responses to endotoxin.

Authors:  T Etoh; E Kakishita; K Nagai
Journal:  Lung       Date:  1984       Impact factor: 2.584

7.  Sensitive assay for plasminogen activator of transformed cells.

Authors:  H Y Liu; G A Peltz; S P Leytus; C Livingston; J Brocklehurst; W F Mangel
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

8.  In vitro fibrinolytic activity and viability of rat alveolar macrophages treated with inflammation generating mineral dusts.

Authors:  K Donaldson; J Slight; R E Bolton
Journal:  Agents Actions       Date:  1987-02

9.  Induction of macrophage plasminogen activator by asbestos is independent of PKC activation.

Authors:  D Lison; F Raguzzi; R Lauwerys
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

10.  Protease-activated "prodrugs" for cancer chemotherapy.

Authors:  P L Carl; P K Chakravarty; J A Katzenellenbogen; M J Weber
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

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