Literature DB >> 1003077

Embryological study of a T/t locus mutation (tw73) affecting trophectoderm development.

M Spiegelman, K Artzt, D Bennett.   

Abstract

Mouse embryos homozygous for the recessive lethal mutation tw73 show specific defects in trophectoderm shortly after implantation. The trophectoderm and ectoplacental cone fail to form the usual close association with the uterine decidua, and proliferation is markedly reduced. The embryo proper ceases to develop beyond the two-layered stage and degenerates and dies within 5 days of implantation.

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Mesh:

Year:  1976        PMID: 1003077

Source DB:  PubMed          Journal:  J Embryol Exp Morphol        ISSN: 0022-0752


  3 in total

1.  Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA.

Authors:  G J Kargul; R Nagaraja; T Shimada; M J Grahovac; M K Lim; H Nakashima; P Waeltz; P Ma; E Chen; D Schlessinger; M S Ko
Journal:  Genome Res       Date:  2000-07       Impact factor: 9.043

2.  Development of velvet coat (Ve/Ve), another early lethal mutation in the house mouse.

Authors:  N H Granholm; L C Stevens; K Theiler
Journal:  Anat Embryol (Berl)       Date:  1979-10

3.  The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.

Authors:  N Schweifer; D P Barlow
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

  3 in total

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