| Literature DB >> 10030549 |
Y Kawai1, Y Nakagawa, T Matuyama, K Akagawa, K Itagawa, K Fukase, S Kusumoto, M Nishijima, I Yano.
Abstract
Nalpha-[3-(Hexadecanoyloxy)hexadecanoyl]-ornithine is a typical bacterial ornithine-containing lipid (OL). The configuration of the 3-hydroxy fatty acids in the OL was proved to be D by using HPLC with chiral column. For this analysis, Nalpha-(D or L)-[3-(hexadecanoyloxy)hexadecanoyl]-L-ornithine were synthesized and used as standards. The typical bacterial OL, as well as the synthesized one, exhibited strong interleukin-1- and prostaglandin E2-inducing activities, and further, it induced the production of high IgG anti-tetanus toxoid antibodies in mice. The typical OL is expected to be utilized as a nontoxic, potent adjuvant.Entities:
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Year: 1999 PMID： 10030549 DOI： 10.1111/j.1574-695X.1999.tb01718.x
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244