P Unge1. 1. Department of Medicine, Länssjukhuset Gävle Sandviken, Sweden.
Abstract
OBJECTIVE: To evaluate the clinical efficacy of available therapies directed towards Helicobacter pylori eradication. DESIGN: Pooled overall analyses of a limited number of drug combinations regardless of dosage, duration, formulation etc. SUBJECTS: Helicobacter pylori infected patients with or without complications. INTERVENTIONS: Efficacy data from all studies included in the analysis are transformed to or retained as intention to treat data. MAIN OUTCOME: Efficacy is presented as proportion of patients cured from the infection. Confidence intervals are enlarged by 1.5 due to the inferior strength of a pooled analysis. RESULTS: Dual therapies are ineffective. Triple therapies cure 70-90% of the patients. Well documented high efficacy is shown for a proton pump inhibitor plus two antimicrobials. Less studied but effective alternatives are ranitidine-bismuth plus two antimicrobials. CONCLUSION: A proton pump inhibitor plus two antimicrobials is the best validated highly effective type of eradication therapy.
OBJECTIVE: To evaluate the clinical efficacy of available therapies directed towards Helicobacter pylori eradication. DESIGN: Pooled overall analyses of a limited number of drug combinations regardless of dosage, duration, formulation etc. SUBJECTS:Helicobacter pylori infected patients with or without complications. INTERVENTIONS: Efficacy data from all studies included in the analysis are transformed to or retained as intention to treat data. MAIN OUTCOME: Efficacy is presented as proportion of patients cured from the infection. Confidence intervals are enlarged by 1.5 due to the inferior strength of a pooled analysis. RESULTS: Dual therapies are ineffective. Triple therapies cure 70-90% of the patients. Well documented high efficacy is shown for a proton pump inhibitor plus two antimicrobials. Less studied but effective alternatives are ranitidine-bismuth plus two antimicrobials. CONCLUSION: A proton pump inhibitor plus two antimicrobials is the best validated highly effective type of eradication therapy.
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