| Literature DB >> 10028428 |
D Díaz1, M J Bernad Bernad, J Gracia-Mora, C M Escobar Llanos.
Abstract
The solubility behavior and binding constants (Kass) of mebendazole with alpha-, beta-, gamma-, and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) have been investigated in simulated intestinal juice by the Higuchi and Connors method. AL diagrams have been obtained. The equilibrium has also been studied in simulated gastric fluid with HP-beta-CD. The phase solubility, 1H-NMR, and molecular mechanics studies revealed the formation of a 1:1 complex.Entities:
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Year: 1999 PMID： 10028428 DOI： 10.1081/ddc-100102151
Source DB: PubMed Journal: Drug Dev Ind Pharm ISSN： 0363-9045 Impact factor: 3.225