Literature DB >> 10028381

New quinoxaline 1,4-di-N-oxides for treatment of tuberculosis.

Y Sainz1, M E Montoya, F J Martínez-Crespo, M A Ortega, A López de Ceráin, A Monge.   

Abstract

Some quinoxaline 1,4-di-N-oxides derivatives with very different substituents in 2, 3, 6 and 7 positions have been synthesized in order to obtain new hypoxia selective agents. Some of these products have been tested as antituberculosis agents and very interesting results have been obtained from the first screening.

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Year:  1999        PMID： 10028381     DOI： 10.1055/s-0031-1300359

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  9 in total

1.  E-2-[3-(3,4-dichlorophenyl)-1-oxo-2-propenyl]-3-methylquinoxaline-1,4-dioxide: a lead antitubercular agent which alters mitochondrial respiration in rat liver.

Authors:  Umashankar Das; Swagatika Das; Brian Bandy; Dennis K J Gorecki; Jonathan R Dimmock
Journal:  Eur J Med Chem       Date:  2010-07-24       Impact factor: 6.514

2.  Efficacy of quinoxaline-2-carboxylate 1,4-di-N-oxide derivatives in experimental tuberculosis.

Authors:  Esther Vicente; Raquel Villar; Asunción Burguete; Beatriz Solano; Silvia Pérez-Silanes; Ignacio Aldana; Joseph A Maddry; Anne J Lenaerts; Scott G Franzblau; Sang-Hyun Cho; Antonio Monge; Robert C Goldman
Journal:  Antimicrob Agents Chemother       Date:  2008-07-14       Impact factor: 5.191

3.  In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.

Authors:  Raquel Villar; Esther Vicente; Beatriz Solano; Silvia Pérez-Silanes; Ignacio Aldana; Joseph A Maddry; Anne J Lenaerts; Scott G Franzblau; Sang-Hyun Cho; Antonio Monge; Robert C Goldman
Journal:  J Antimicrob Chemother       Date:  2008-05-23       Impact factor: 5.790

4.  Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis.

Authors:  Mery Santivañez-Veliz; Silvia Pérez-Silanes; Enrique Torres; Elsa Moreno-Viguri
Journal:  Bioorg Med Chem Lett       Date:  2016-03-18       Impact factor: 2.823

Review 5.  Recent advances in the transition-metal-free synthesis of quinoxalines.

Authors:  Biplob Borah; L Raju Chowhan
Journal:  RSC Adv       Date:  2021-11-19       Impact factor: 4.036

Review 6.  Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions.

Authors:  Guyue Cheng; Wei Sa; Chen Cao; Liangliang Guo; Haihong Hao; Zhenli Liu; Xu Wang; Zonghui Yuan
Journal:  Front Pharmacol       Date:  2016-03-21       Impact factor: 5.810

7.  In vitro antimicrobial activities of animal-used quinoxaline 1,4-di-N-oxides against mycobacteria, mycoplasma and fungi.

Authors:  Yan Zhao; Guyue Cheng; Haihong Hao; Yuanhu Pan; Zhenli Liu; Menghong Dai; Zonghui Yuan
Journal:  BMC Vet Res       Date:  2016-09-06       Impact factor: 2.741

8.  Unexpected reduction of ethyl 3-phenylquinoxaline-2- carboxylate 1,4-di-N-oxide derivatives by amines.

Authors:  Lidia M Lima; Esther Vicente; Beatriz Solano; Silvia Pérez-Silanes; Ignacio Aldana; Antonio Monge
Journal:  Molecules       Date:  2008-01-17       Impact factor: 4.411

9.  Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.

Authors:  Saioa Ancizu; Elsa Moreno; Enrique Torres; Asunción Burguete; Silvia Pérez-Silanes; Diego Benítez; Raquel Villar; Beatriz Solano; Adoración Marín; Ignacio Aldana; Hugo Cerecetto; Mercedes González; Antonio Monge
Journal:  Molecules       Date:  2009-06-22       Impact factor: 4.411
  9 in total

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