Literature DB >> 1002761

Fracture healing in the presence of chronic hypoxia.

R B Heppenstall, C W Goodwin, C T Brighton.   

Abstract

Recent studies have demonstrated that fracture healing normally takes place under hypoxic conditions. The present study evaluated the effect of a state of chronic systemic hypoxia on fracture healing in dogs. A significant delay in fracture healing was demonstrated in the hypoxic animals roentgenographically, histologically, and by strength-testing criteria. A further reduction in the available oxygen supply below that present during normal repair had an adverse effect on fracture healing.

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Year:  1976        PMID: 1002761

Source DB:  PubMed          Journal:  J Bone Joint Surg Am        ISSN: 0021-9355            Impact factor:   5.284


  13 in total

1.  Prevention and Treatment of Postsurgical Head and Neck Infections.

Authors:  Rebecca Fraioli; Jonas T. Johnson
Journal:  Curr Infect Dis Rep       Date:  2004-06       Impact factor: 3.725

2.  Hypoxia increases Annexin A2 expression in osteoblastic cells via VEGF and ERK.

Authors:  Damian C Genetos; Alice Wong; Shinya Watari; Clare E Yellowley
Journal:  Bone       Date:  2010-09-15       Impact factor: 4.398

3.  EGCG ameliorates the hypoxia-induced apoptosis and osteogenic differentiation reduction of mesenchymal stem cells via upregulating miR-210.

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Journal:  Mol Biol Rep       Date:  2016-01-16       Impact factor: 2.316

4.  Hypoxia-induced HMGB1 in would tissues promotes the osteoblast cell proliferation via activating ERK/JNK signaling.

Authors:  Qiang Li; Bin Yu; Peng Yang
Journal:  Int J Clin Exp Med       Date:  2015-09-15

5.  Effects of hypoxia on osteogenic differentiation of rat bone marrow mesenchymal stem cells.

Authors:  Yating Wang; Juan Li; Yanmin Wang; Lei Lei; Chunmiao Jiang; Shu An; Yuxiang Zhan; Qian Cheng; Zhihe Zhao; Jun Wang; Lingyong Jiang
Journal:  Mol Cell Biochem       Date:  2011-12-25       Impact factor: 3.396

6.  Additive and synergistic effects of bFGF and hypoxia on leporine meniscus cell-seeded PLLA scaffolds.

Authors:  Najmuddin J Gunja; Kyriacos A Athanasiou
Journal:  J Tissue Eng Regen Med       Date:  2010-02       Impact factor: 3.963

7.  Tibial fracture decreases oxygen levels at the site of injury.

Authors:  Chuanyong Lu; Mark Rollins; Huagang Hou; Harold M Swartz; Harriet Hopf; Theodore Miclau; Ralph S Marcucio
Journal:  Iowa Orthop J       Date:  2008

8.  Metabolic utilization of human osteoblast cell line hFOB 1.19 under normoxic and hypoxic conditions: A phenotypic microarray analysis.

Authors:  Yan Chao Cui; Yu Sheng Qiu; Qiong Wu; Gang Bu; Amira Peli; Seoh Wei Teh; Kok Pian Ang; Narcisse Ms Joseph; Avin Ee-Hwan Koh; Aisha Farhana; Badr Alzahrani; Mohammed Safwan Ali Khan; Antony V Samrot; Pooi Ling Mok; Suresh Kumar Subbiah
Journal:  Exp Biol Med (Maywood)       Date:  2021-02-03

9.  Titanium Oxide: A Bioactive Factor in Osteoblast Differentiation.

Authors:  P Santiago-Medina; P A Sundaram; N Diffoot-Carlo
Journal:  Int J Dent       Date:  2015-11-18

10.  Hyperbaric hyperoxia accelerates fracture healing in mice.

Authors:  Shigeo Kawada; Eiji Wada; Ryoichi Matsuda; Naokata Ishii
Journal:  PLoS One       Date:  2013-08-14       Impact factor: 3.240

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