Literature DB >> 10025713

Immunocytochemical localization of prostaglandin EP3 receptor in the rat hypothalamus.

K Nakamura1, T Kaneko, Y Yamashita, H Hasegawa, H Katoh, A Ichikawa, M Negishi.   

Abstract

A rabbit antibody against an N-terminal portion of rat prostaglandin EP3 receptor (EP3R) was produced to examine the distribution of EP3R in the rat hypothalamus. The antibody specifically recognized EP3R proteins in rat brain extract, in membrane fractions of rat kidney, and in membrane fractions of EP3R-expressing culture cells. Intense EP3R-like immunoreactivity was observed in the median preoptic nucleus, medial preoptic area, parastrial nucleus, compact part of the dorsomedial hypothalamic nucleus, and dorsal part of the premammillary nucleus. These results suggest that prostaglandin E2 mediates various actions in the hypothalamus, such as fever induction in the preoptic area, through EP3R.

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Year:  1999        PMID： 10025713     DOI： 10.1016/s0304-3940(98)00962-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  24 in total

1.  The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area.

Authors:  Kazuhiro Nakamura; Kiyoshi Matsumura; Takeshi Kaneko; Shigeo Kobayashi; Hironori Katoh; Manabu Negishi
Journal:  J Neurosci       Date:  2002-06-01       Impact factor: 6.167

2.  A thermosensory pathway that controls body temperature.

Authors:  Kazuhiro Nakamura; Shaun F Morrison
Journal:  Nat Neurosci       Date:  2007-12-16       Impact factor: 24.884

3.  Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus.

Authors:  Yoshiko Nakamura; Kazuhiro Nakamura; Kiyoshi Matsumura; Shigeo Kobayashi; Takeshi Kaneko; Shaun F Morrison
Journal:  Eur J Neurosci       Date:  2005-12       Impact factor: 3.386

Review 4.  Central control of thermogenesis in mammals.

Authors:  Shaun F Morrison; Kazuhiro Nakamura; Christopher J Madden
Journal:  Exp Physiol       Date:  2008-05-09       Impact factor: 2.969

5.  Dorsomedial hypothalamus mediates autonomic, neuroendocrine, and locomotor responses evoked from the medial preoptic area.

Authors:  Joseph L Hunt; Dmitry V Zaretsky; Sumit Sarkar; Joseph A Dimicco
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-11-18       Impact factor: 3.619

6.  Central efferent pathways for cold-defensive and febrile shivering.

Authors:  Kazuhiro Nakamura; Shaun F Morrison
Journal:  J Physiol       Date:  2011-05-24       Impact factor: 5.182

Review 7.  Central nervous system regulation of brown adipose tissue.

Authors:  Shaun F Morrison; Christopher J Madden
Journal:  Compr Physiol       Date:  2014-10       Impact factor: 9.090

Review 8.  Central nervous system circuits that control body temperature.

Authors:  Christopher J Madden; Shaun F Morrison
Journal:  Neurosci Lett       Date:  2018-12-23       Impact factor: 3.046

9.  Downregulation of prostaglandin E receptor subtype EP3 during colon cancer development.

Authors:  Y Shoji; M Takahashi; T Kitamura; K Watanabe; T Kawamori; T Maruyama; Y Sugimoto; M Negishi; S Narumiya; T Sugimura; K Wakabayashi
Journal:  Gut       Date:  2004-08       Impact factor: 23.059

10.  Galanin-like peptide (GALP) facilitates thermogenesis via synthesis of prostaglandin E2 by astrocytes in the periventricular zone of the third ventricle.

Authors:  Haruaki Kageyama; Kei Endo; Toshimasa Osaka; Jun Watanabe; Li Hua Wang; Kazuo Ito; Mamiko Suzuki; Junichi Sakagami; Fumiko Takenoya; Seiji Shioda
Journal:  J Mol Neurosci       Date:  2013-01-26       Impact factor: 3.444
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