Literature DB >> 10025608

Sodium NMR evaluation of articular cartilage degradation.

E K Insko1, J H Kaufman, J S Leigh, R Reddy.   

Abstract

One of the first effects of degenerative osteoarthritis is the loss of proteoglycans from the matrix of articular cartilage. Using a model of osteoarthritic change where the cartilage has been enzymatically degraded with trypsin, the sodium NMR characteristics of the cartilage were determined as a function of changes in the proteoglycan content. The results demonstrate that the single quantum sodium signal decreases as the proteoglycan content of the cartilage matrix decreases. In addition, the relaxation characteristics of the sodium change such that the T1 is longer, the T2s is longer, and the T2f is shorter. Short echo-time, T1-weighted sodium images are presented which demonstrate that this information may be utilized to detect the loss of proteoglycans from articular cartilage.

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Year:  1999        PMID： 10025608     DOI： 10.1002/(sici)1522-2594(199901)41:1<30::aid-mrm6>3.0.co;2-u

Source DB:  PubMed          Journal:  Magn Reson Med        ISSN： 0740-3194            Impact factor:   4.668


  25 in total

1.  23Na MRI accurately measures fixed charge density in articular cartilage.

Authors:  Erik M Shapiro; Arijitt Borthakur; Alexander Gougoutas; Ravinder Reddy
Journal:  Magn Reson Med       Date:  2002-02       Impact factor: 4.668

2.  In vitro degradation of articular cartilage: does trypsin treatment produce consistent results?

Authors:  H R Moody; C P Brown; J C Bowden; R W Crawford; D L S McElwain; A O Oloyede
Journal:  J Anat       Date:  2006-08       Impact factor: 2.610

Review 3.  MR imaging of articular cartilage physiology.

Authors:  Jung-Ah Choi; Garry E Gold
Journal:  Magn Reson Imaging Clin N Am       Date:  2011-05       Impact factor: 2.266

Review 4.  Quantitative techniques for musculoskeletal MRI at 7 Tesla.

Authors:  Neal K Bangerter; Meredith D Taylor; Grayson J Tarbox; Antony J Palmer; Daniel J Park
Journal:  Quant Imaging Med Surg       Date:  2016-12

5.  23Na multiple quantum filtered NMR characterisation of Na+ binding and dynamics in animal cells: a comparative study and effect of Na+/Li + competition.

Authors:  Carla P Fonseca; Luís L Fonseca; Liliana P Montezinho; Paula M Alves; Helena Santos; M Margarida C A Castro; Carlos F G C Geraldes
Journal:  Eur Biophys J       Date:  2013-04-06       Impact factor: 1.733

Review 6.  Quantitative sodium magnetic resonance imaging of cartilage, muscle, and tendon.

Authors:  Neal K Bangerter; Grayson J Tarbox; Meredith D Taylor; Joshua D Kaggie
Journal:  Quant Imaging Med Surg       Date:  2016-12

7.  Water magnetic relaxation dispersion in biological systems: the contribution of proton exchange and implications for the noninvasive detection of cartilage degradation.

Authors:  U Duvvuri; A D Goldberg; J K Kranz; L Hoang; R Reddy; F W Wehrli; A J Wand; S W Englander; J S Leigh
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-16       Impact factor: 11.205

Review 8.  Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage.

Authors:  Arijitt Borthakur; Eric Mellon; Sampreet Niyogi; Walter Witschey; J Bruce Kneeland; Ravinder Reddy
Journal:  NMR Biomed       Date:  2006-11       Impact factor: 4.044

9.  The application of 23Na double-quantum-filter (DQF) NMR spectroscopy for the study of spinal disc degeneration.

Authors:  Kristopher J Ooms; Marco Cannella; Alexander J Vega; Michele Marcolongo; Tatyana Polenova
Journal:  Magn Reson Med       Date:  2008-08       Impact factor: 4.668

Review 10.  Quantitative radiologic imaging techniques for articular cartilage composition: toward early diagnosis and development of disease-modifying therapeutics for osteoarthritis.

Authors:  Edwin H G Oei; Jasper van Tiel; William H Robinson; Garry E Gold
Journal:  Arthritis Care Res (Hoboken)       Date:  2014-08       Impact factor: 4.794
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