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Literature DB >> 10024246

Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors.

A Patapoutian¹, C Backus, A Kispert, L F Reichardt.

Abstract

Neurotrophins regulate survival, axonal growth, and target innervation of sensory and other neurons. Neurotrophin-3 (NT-3) is expressed specifically in cells adjacent to extending axons of dorsal root ganglia neurons, and its absence results in loss of most of these neurons before their axons reach their targets. However, axons are not required for NT-3 expression in limbs; instead, local signals from ectoderm induce NT-3 expression in adjacent mesenchyme. Wnt factors expressed in limb ectoderm induce NT-3 in the underlying mesenchyme. Thus, epithelial-mesenchymal interactions mediated by Wnt factors control NT-3 expression and may regulate axonal growth and guidance.

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Year: 1999 PMID： 10024246 PMCID： PMC2710127 DOI： 10.1126/science.283.5405.1180

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

15 in total

1. Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors.

Authors: I Fariñas; C K Yoshida; C Backus; L F Reichardt
Journal: Neuron Date: 1996-12 Impact factor: 17.173

2. Neurotrophin-3 is a survival factor in vivo for early mouse trigeminal neurons.

Authors: G A Wilkinson; I Fariñas; C Backus; C K Yoshida; L F Reichardt
Journal: J Neurosci Date: 1996-12-01 Impact factor: 6.167

3. Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3.

Authors: D J Epstein; M Vekemans; P Gros
Journal: Cell Date: 1991-11-15 Impact factor: 41.582

4. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.

Authors: I Fariñas; K R Jones; C Backus; X Y Wang; L F Reichardt
Journal: Nature Date: 1994-06-23 Impact factor: 49.962

5. A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells.

Authors: W M ElShamy; P Ernfors
Journal: Neuron Date: 1996-05 Impact factor: 17.173

6. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

Authors: C van Genderen; R M Okamura; I Fariñas; R G Quo; T G Parslow; L Bruhn; R Grosschedl
Journal: Genes Dev Date: 1994-11-15 Impact factor: 11.361

7. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

Authors: T Serafini; T E Kennedy; M J Galko; C Mirzayan; T M Jessell; M Tessier-Lavigne
Journal: Cell Date: 1994-08-12 Impact factor: 41.582

8. The Splotch (Sp1H) and Splotch-delayed (Spd) alleles: differential phenotypic effects on neural crest and limb musculature.

Authors: T Franz
Journal: Anat Embryol (Berl) Date: 1993-04

Regulation of neurotrophin-3 expression by epithelial-mesenchymal interactions: the role of Wnt factors.

1. Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors.

2. Neurotrophin-3 is a survival factor in vivo for early mouse trigeminal neurons.

3. Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3.

4. Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.

5. A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells.

6. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

7. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6.

8. The Splotch (Sp1H) and Splotch-delayed (Spd) alleles: differential phenotypic effects on neural crest and limb musculature.

9. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney.

10. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.

Review 1. Roles of Wnt proteins in neural development and maintenance.

Review 2. Neurotrophins: roles in neuronal development and function.

Review 3. Regulation of neuronal survival and death by extracellular signals during development.

Review 4. Molecular control of the neural crest and peripheral nervous system development.

5. Smooth-muscle-specific expression of neurotrophin-3 in mouse embryonic and neonatal gastrointestinal tract.

Review 6. Neurotrophin-regulated signalling pathways.

7. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate.

8. Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis.

9. Factors regulating vagal sensory development: potential role in obesities of developmental origin.

10. Louis Reichardt: the long climb to science's summits.