OBJECTIVE: To study the relationship between human immunodeficiency virus (HIV) infection and body weight in African women during and after pregnancy. METHODS: A prospective cohort study was initiated at the Centre Hospitalier de Kigali in July 1992. Every woman seen at the antenatal clinic and with a gestational age of <28 weeks was offered HIV-1 antibody testing. Comparable numbers of HIV-infected (HIV+) and uninfected (HIV-) women were recruited. At inclusion, socio-demographic characteristics and self-reported pre-pregnancy weight were recorded; height and weight were measured. Each woman enrolled had a monthly follow-up until 9 months after delivery, with a clinical examination including weighing. Three anthropometric indices were used to answer the study objectives: weight, body mass index (BMI), and pregnancy balance. RESULTS: As of April 1994, 101 HIV+ and 106 HIV- women were followed until 5 months after delivery. Weight and BMI during pregnancy were lower in HIV+ women than in HIV- women. After delivery, weight and BMI gains were significantly lower in HIV+ women. Until 5 months after delivery, the mean weight variation was -2.2 kg (standard deviation [SD] = 5.9 kg) in HIV+ women and +0.2 kg (SD = 6.6 kg) in HIV- women (P = 0.007) in comparison to pre-pregnancy weight. Comparisons of the slopes of the weight curves did not show statistical differences throughout the pregnancy, but it did during the post-partum period (P = 0.02). CONCLUSIONS: Our study suggests that HIV infection could impair nutritional status in pregnant women, especially during the post-partum period. Family planning and maternal and child health services including HIV testing and counselling, should consider a nutritional assessment and intervention programme targeted to HIV+ pregnant women.
OBJECTIVE: To study the relationship between human immunodeficiency virus (HIV) infection and body weight in African women during and after pregnancy. METHODS: A prospective cohort study was initiated at the Centre Hospitalier de Kigali in July 1992. Every woman seen at the antenatal clinic and with a gestational age of <28 weeks was offered HIV-1 antibody testing. Comparable numbers of HIV-infected (HIV+) and uninfected (HIV-) women were recruited. At inclusion, socio-demographic characteristics and self-reported pre-pregnancy weight were recorded; height and weight were measured. Each woman enrolled had a monthly follow-up until 9 months after delivery, with a clinical examination including weighing. Three anthropometric indices were used to answer the study objectives: weight, body mass index (BMI), and pregnancy balance. RESULTS: As of April 1994, 101 HIV+ and 106 HIV- women were followed until 5 months after delivery. Weight and BMI during pregnancy were lower in HIV+ women than in HIV- women. After delivery, weight and BMI gains were significantly lower in HIV+ women. Until 5 months after delivery, the mean weight variation was -2.2 kg (standard deviation [SD] = 5.9 kg) in HIV+ women and +0.2 kg (SD = 6.6 kg) in HIV- women (P = 0.007) in comparison to pre-pregnancy weight. Comparisons of the slopes of the weight curves did not show statistical differences throughout the pregnancy, but it did during the post-partum period (P = 0.02). CONCLUSIONS: Our study suggests that HIV infection could impair nutritional status in pregnant women, especially during the post-partum period. Family planning and maternal and child health services including HIV testing and counselling, should consider a nutritional assessment and intervention programme targeted to HIV+ pregnant women.
Authors: Valerie L Flax; Margaret E Bentley; Charles S Chasela; Dumbani Kayira; Michael G Hudgens; Rodney J Knight; Alice Soko; Denise J Jamieson; Charles M van der Horst; Linda S Adair Journal: J Nutr Date: 2012-05-30 Impact factor: 4.798
Authors: Pamela M Murnane; Stephen M Arpadi; Moses Sinkala; Chipepo Kankasa; Mwiya Mwiya; Prisca Kasonde; Donald M Thea; Grace M Aldrovandi; Louise Kuhn Journal: Int J Epidemiol Date: 2010-05-19 Impact factor: 7.196
Authors: Roshan T Ramlal; Martin Tembo; Alice Soko; Maggie Chigwenembe; Beth C Tohill; Dumbani Kayira; Caroline C King; Charles Chasela; Denise Jamieson; Charles van der Horst; Margaret E Bentley; Linda S Adair Journal: Matern Child Health J Date: 2013-02
Authors: Eric Nagaonlé Somé; Ingunn M S Engebretsen; Nicolas Nagot; Nicolas Y Meda; Roselyne Vallo; Chipepo Kankasa; James K Tumwine; Mandisa Singata; Justus G Hofmeyr; Philippe Van de Perre; Thorkild Tylleskär Journal: PLoS One Date: 2017-05-09 Impact factor: 3.240
Authors: Eric Nagaonle Somé; Ingunn M S Engebretsen; Nicolas Nagot; Nicolas Yelbomkan Meda; Roselyne Vallo; Chipepo Kankasa; James K Tumwine; Mandisa Singata-Madliki; Kim Harper; G Justus Hofmeyr; Philippe Van de Perre; Thorkild Tylleskär Journal: BMJ Open Date: 2018-04-05 Impact factor: 2.692