Literature DB >> 10024051

Decreasing levels of anti-Nef antibody correlate with increasing HIV type 1 viral loads and AIDS disease progression.

Y M Chen1, R H Lin, C M Lee, C Y Fu, S C Chen, W J Syu.   

Abstract

To study the association between anti-Gag and anti-Nef antibody reactivities and their correlations with disease progression, 174 HIV-1/AIDS patients were followed up for 1 year after they received triple therapy. The antibody reactivities were analyzed using a Western blot test with recombinant Gag and Nef proteins. The results showed that decreasing levels of anti-Gag or anti-Nef antibody correlate with disease progression defined by HIV-1 viral loads or T4 cell counts. After receiving triple treatment for 1 year, 8 of 38 (21.1%) Nef antibody-negative patients became positive, while only 9 of 125 (7.2%) Nef antibody-positive persons lost the antibody reactivity (p < 0.01). Therefore, HIV-1 Nef may serve as a clinical marker of disease progression.

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Year:  1999        PMID： 10024051     DOI： 10.1089/088922299311691

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  5 in total

1.  Characterization of Nef-CXCR4 interactions important for apoptosis induction.

Authors:  Ming-Bo Huang; Ling Ling Jin; Cleve O James; Mahfuz Khan; Michael D Powell; Vincent C Bond
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

Review 2.  Building collaborative networks for HIV/AIDS vaccine development: the AVIP experience.

Authors:  Flavia Ferrantelli; Stefano Buttò; Aurelio Cafaro; Britta Wahren; Barbara Ensoli
Journal:  Springer Semin Immunopathol       Date:  2006-09-16

3.  Open reading frame 8a of the human severe acute respiratory syndrome coronavirus not only promotes viral replication but also induces apoptosis.

Authors:  Chia-Yen Chen; Yueh-Hsin Ping; Hsin-Chen Lee; Kuan-Hsuan Chen; Yuan-Ming Lee; Yu-Juin Chan; Te-Cheng Lien; Tjin-Shing Jap; Chi-Hung Lin; Lung-Sen Kao; Yi-Ming Arthur Chen
Journal:  J Infect Dis       Date:  2007-06-19       Impact factor: 5.226

4.  Hyperattenuated recombinant influenza A virus nonstructural-protein-encoding vectors induce human immunodeficiency virus type 1 Nef-specific systemic and mucosal immune responses in mice.

Authors:  B Ferko; J Stasakova; S Sereinig; J Romanova; D Katinger; B Niebler; H Katinger; A Egorov
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

5.  Use of principal components analysis and protein microarray to explore the association of HIV-1-specific IgG responses with disease progression.

Authors:  Helen L Gerns Storey; Barbra A Richardson; Benson Singa; Jackie Naulikha; Vivian C Prindle; Vladimir E Diaz-Ochoa; Phil L Felgner; David Camerini; Helen Horton; Grace John-Stewart; Judd L Walson
Journal:  AIDS Res Hum Retroviruses       Date:  2013-12-09       Impact factor: 2.205
  5 in total

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