Literature DB >> 10023074

Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.

T Kawai1, H Sanjo, S Akira.   

Abstract

We show here the identification of Duet, a novel molecule bearing serine/threonine kinase, Dbl-Homology (DH), and Pleckstrin-Homology (PH) domains. The kinase domain of Duet shows a homology to that of DAP kinase that is involved in apoptosis, and Duet is autophosphorylated by an in-vitro kinase assay. The DH- and PH-domains are closely related to those of Trio and Kalirin. Trad mRNA is specifically expressed in skeletal muscle. Duet protein was localized to actin-associated cytoskeletal elements. These data suggest a role of Duet in the cytoskeleton-dependent cell function.

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Year:  1999        PMID： 10023074     DOI： 10.1016/s0378-1119(98)00605-2

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  13 in total

Review 1.  Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.

Authors:  Mohamed Aittaleb; Cassandra A Boguth; John J G Tesmer
Journal:  Mol Pharmacol       Date:  2009-10-30       Impact factor: 4.436

2.  Rho-guanine nucleotide exchange factors during development: Force is nothing without control.

Authors:  Shai Mulinari; Udo Häcker
Journal:  Small GTPases       Date:  2010-07

3.  Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching.

Authors:  Yan Yan; Betty A Eipper; Richard E Mains
Journal:  Cereb Cortex       Date:  2014-08-21       Impact factor: 5.357

Review 4.  KALRN: A central regulator of synaptic function and synaptopathies.

Authors:  Euan Parnell; Lauren P Shapiro; Roos A Voorn; Marc P Forrest; Hiba A Jalloul; Daniel D Loizzo; Peter Penzes
Journal:  Gene       Date:  2020-11-13       Impact factor: 3.688

5.  The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans.

Authors:  Robert Steven; Lijia Zhang; Joseph Culotti; Tony Pawson
Journal:  Genes Dev       Date:  2005-09-01       Impact factor: 11.361

6.  Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.

Authors:  S P O'Brien; K Seipel; Q G Medley; R Bronson; R Segal; M Streuli
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

7.  Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT).

Authors:  Jennifer J L Hodas; Anne Nehring; Nicole Höche; Michael J Sweredoski; Rainer Pielot; Sonja Hess; David A Tirrell; Daniela C Dieterich; Erin M Schuman
Journal:  Proteomics       Date:  2012-08       Impact factor: 3.984

Review 8.  Trio family proteins as regulators of cell migration and morphogenesis in development and disease - mechanisms and cellular contexts.

Authors:  Josie E Bircher; Anthony J Koleske
Journal:  J Cell Sci       Date:  2021-02-10       Impact factor: 5.285

9.  Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.

Authors:  Prashant Mandela; Yan Yan; Taylor LaRese; Betty A Eipper; Richard E Mains
Journal:  Horm Behav       Date:  2014-07-09       Impact factor: 3.587

10.  Kalrn plays key roles within and outside of the nervous system.

Authors:  Prashant Mandela; Maya Yankova; Lisa H Conti; Xin-Ming Ma; James Grady; Betty A Eipper; Richard E Mains
Journal:  BMC Neurosci       Date:  2012-11-01       Impact factor: 3.288
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