| Literature DB >> 10022126 |
J Cook1, S Krishnan, S Ananth, S F Sells, Y Shi, M M Walther, W M Linehan, V P Sukhatme, M H Weinstein, V M Rangnekar.
Abstract
Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma.Entities:
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Year: 1999 PMID： 10022126 DOI： 10.1038/sj.onc.1202416
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867