Literature DB >> 10021946

Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)- 3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent.

W N Chan1, J M Evans, M S Hadley, H J Herdon, J C Jerman, A A Parsons, S J Read, T O Stean, M Thompson, N Upton.   

Abstract

Optimisation of novel cis- and trans-4-(substituted-amido)benzopyran-3-ol derivatives has led to the identification of SB-220453 20 with an in vivo pre-clinical CNS profile predictive of potential antimigraine activity.

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Year:  1999        PMID： 10021946     DOI： 10.1016/s0960-894x(98)00728-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes.

Authors:  A A Parsons; S Bingham; P Raval; S Read; M Thompson; N Upton
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

2.  Tonabersat Prevents Inflammatory Damage in the Central Nervous System by Blocking Connexin43 Hemichannels.

Authors:  Yeri Kim; Jarred M Griffin; Mohd N Mat Nor; Jie Zhang; Peter S Freestone; Helen V Danesh-Meyer; Ilva D Rupenthal; Monica Acosta; Louise F B Nicholson; Simon J O'Carroll; Colin R Green
Journal:  Neurotherapeutics       Date:  2017-10       Impact factor: 7.620

Review 3.  Animal migraine models for drug development: status and future perspectives.

Authors:  Inger Jansen-Olesen; Peer Tfelt-Hansen; Jes Olesen
Journal:  CNS Drugs       Date:  2013-12       Impact factor: 5.749

Review 4.  Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine.

Authors:  P L Durham; F G Garrett
Journal:  Cephalalgia       Date:  2009-11       Impact factor: 6.292

Review 5.  Cortical spreading depression: its role in migraine pathogenesis and possible therapeutic intervention strategies.

Authors:  Andrew A Parsons
Journal:  Curr Pain Headache Rep       Date:  2004-10

Review 6.  Involvement of gap junction channels in the pathophysiology of migraine with aura.

Authors:  Denis Sarrouilhe; Catherine Dejean; Marc Mesnil
Journal:  Front Physiol       Date:  2014-02-25       Impact factor: 4.566

Review 7.  Influence of drugs on gap junctions in glioma cell lines and primary astrocytes in vitro.

Authors:  Zahra Moinfar; Hannes Dambach; Pedro M Faustmann
Journal:  Front Physiol       Date:  2014-05-16       Impact factor: 4.566

Review 8.  Reactive Astrocytes in Brain Metastasis.

Authors:  David Wasilewski; Neibla Priego; Coral Fustero-Torre; Manuel Valiente
Journal:  Front Oncol       Date:  2017-12-11       Impact factor: 6.244

9.  Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS.

Authors:  Akshata A Almad; Arens Taga; Jessica Joseph; Sarah K Gross; Connor Welsh; Aneesh Patankar; Jean-Philippe Richard; Khalil Rust; Aayush Pokharel; Caroline Plott; Mauricio Lillo; Raha Dastgheyb; Kevin Eggan; Norman Haughey; Jorge E Contreras; Nicholas J Maragakis
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-21       Impact factor: 12.779

10.  Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.

Authors:  Qing Chen; Adrienne Boire; Xin Jin; Manuel Valiente; Ekrem Emrah Er; Alejandro Lopez-Soto; Leni Jacob; Ruzeen Patwa; Hardik Shah; Ke Xu; Justin R Cross; Joan Massagué
Journal:  Nature       Date:  2016-05-18       Impact factor: 49.962
  10 in total

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