Literature DB >> 10021939

N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists.

Y P Auberson1, P Acklin, S Bischoff, R Moretti, S Ofner, M Schmutz, S J Veenstra.   

Abstract

N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine-binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsant effects in the electroshock-induced convulsion assay in mice.

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Year:  1999        PMID： 10021939     DOI： 10.1016/s0960-894x(98)00720-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits.

Authors:  Konkallu Hanumae Gowd; Tiffany S Han; Vernon Twede; Joanna Gajewiak; Misty D Smith; Maren Watkins; Randall J Platt; Gabriela Toledo; H Steve White; Baldomero M Olivera; Grzegorz Bulaj
Journal:  Biochemistry       Date:  2012-05-30       Impact factor: 3.162

2.  An Overview of Stereoselective Synthesis of α-Aminophosphonic Acids and Derivatives.

Authors:  Mario Ordóñez; Haydée Rojas-Cabrera; Carlos Cativiela
Journal:  Tetrahedron       Date:  2009-01-03       Impact factor: 2.457

3.  From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes.

Authors:  Randall J Platt; Kigen J Curtice; Vernon D Twede; Maren Watkins; Paweł Gruszczyński; Grzegorz Bulaj; Martin P Horvath; Baldomero M Olivera
Journal:  Toxicon       Date:  2014-02-07       Impact factor: 3.033

Review 4.  Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.

Authors:  Kasper B Hansen; Lonnie P Wollmuth; Derek Bowie; Hiro Furukawa; Frank S Menniti; Alexander I Sobolevsky; Geoffrey T Swanson; Sharon A Swanger; Ingo H Greger; Terunaga Nakagawa; Chris J McBain; Vasanthi Jayaraman; Chian-Ming Low; Mark L Dell'Acqua; Jeffrey S Diamond; Chad R Camp; Riley E Perszyk; Hongjie Yuan; Stephen F Traynelis
Journal:  Pharmacol Rev       Date:  2021-10       Impact factor: 18.923

5.  Prolongation of levodopa responses by glycineB antagonists in parkinsonian primates.

Authors:  Stella M Papa; Yves P Auberson; J Timothy Greenamyre
Journal:  Ann Neurol       Date:  2004-11       Impact factor: 10.422

6.  Unmasking GluN1/GluN3A excitatory glycine NMDA receptors.

Authors:  Teddy Grand; Sarah Abi Gerges; Mélissa David; Marco A Diana; Pierre Paoletti
Journal:  Nat Commun       Date:  2018-11-13       Impact factor: 14.919
  6 in total

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