Literature DB >> 10021926

In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones.

M Kawase1, H Harada, S Saito, J Cui, S Tani.   

Abstract

Heteroaromatic trifluoromethyl ketones (TFMK's) showed strong inhibitory activity against Helicobacter pylori. The MIC50 observed for 2-trifluoroacetonylbenzoxazole (1) is 20-fold more active than metronidazole and is only twice as high as that of clarithromycin. The inhibitory mode of TFMK's on Hp growth was not related to inhibition of urease.

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Year:  1999        PMID： 10021926     DOI： 10.1016/s0960-894x(98)00726-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system.

Authors:  Yamato Fujihira; Yumeng Liang; Makoto Ono; Kazuki Hirano; Takumi Kagawa; Norio Shibata
Journal:  Beilstein J Org Chem       Date:  2021-02-12       Impact factor: 2.883

2.  Synthesis and characterisation of κ2-N,O-oxazoline-enolate complexes of nickel(ii): explorations in coordination chemistry and metal-mediated polymerisation.

Authors:  Jeanette A Adjei; Alan J Lough; Robert A Gossage
Journal:  RSC Adv       Date:  2019-01-29       Impact factor: 4.036

3.  Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae).

Authors:  Adriana Basile; Sergio Sorbo; Vivienne Spadaro; Maurizio Bruno; Antonella Maggio; Nicoletta Faraone; Sergio Rosselli
Journal:  Molecules       Date:  2009-02-27       Impact factor: 4.411
  3 in total

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