Literature DB >> 10021423

How do peptide synthetases generate structural diversity?

D Konz1, M A Marahiel.   

Abstract

Many low-molecular-weight peptides of microbial origin are synthesized nonribosomally on large multifunctional proteins, termed peptide synthetases. These enzymes contain repeated building blocks in which several defined domains catalyze specific reactions of peptide synthesis. The order of these domains within the enzyme determines the sequence and structure of the peptide product.

Mesh:

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Year:  1999        PMID: 10021423     DOI: 10.1016/S1074-5521(99)80002-7

Source DB:  PubMed          Journal:  Chem Biol        ISSN: 1074-5521


  46 in total

Review 1.  Genetics and assembly line enzymology of siderophore biosynthesis in bacteria.

Authors:  Jorge H Crosa; Christopher T Walsh
Journal:  Microbiol Mol Biol Rev       Date:  2002-06       Impact factor: 11.056

2.  Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009.

Authors:  Jeff Pootoolal; Michael G Thomas; C Gary Marshall; John M Neu; Brian K Hubbard; Christopher T Walsh; Gerard D Wright
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

3.  Analysis of a nonribosomal peptide synthetase gene from Alternaria brassicae and flanking genomic sequences.

Authors:  Thomas Guillemette; Adnane Sellam; Philippe Simoneau
Journal:  Curr Genet       Date:  2004-01-15       Impact factor: 3.886

4.  Culturable endophytes of medicinal plants and the genetic basis for their bioactivity.

Authors:  Kristin I Miller; Chen Qing; Daniel Man-Yuen Sze; Basil D Roufogalis; Brett A Neilan
Journal:  Microb Ecol       Date:  2012-03-21       Impact factor: 4.552

5.  New PCR primers for the screening of NRPS and PKS-I systems in actinomycetes: detection and distribution of these biosynthetic gene sequences in major taxonomic groups.

Authors:  A Ayuso-Sacido; O Genilloud
Journal:  Microb Ecol       Date:  2004-12-21       Impact factor: 4.552

6.  Bacteria of the Roseobacter clade show potential for secondary metabolite production.

Authors:  Torben Martens; Lone Gram; Hans-Peter Grossart; Daniel Kessler; Rolf Müller; Meinhard Simon; Silke C Wenzel; Thorsten Brinkhoff
Journal:  Microb Ecol       Date:  2007-03-10       Impact factor: 4.552

7.  Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.

Authors:  C Bihlmaier; E Welle; C Hofmann; K Welzel; A Vente; E Breitling; M Müller; S Glaser; A Bechthold
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

8.  Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases.

Authors:  Kristjan Bloudoff; Dmitry Rodionov; T Martin Schmeing
Journal:  J Mol Biol       Date:  2013-06-10       Impact factor: 5.469

9.  Structural characterization of actinomycin D using multiple ion isolation and electron induced dissociation.

Authors:  Rebecca H Wills; Peter B O'Connor
Journal:  J Am Soc Mass Spectrom       Date:  2013-12-03       Impact factor: 3.109

10.  Lipopeptide production in Pseudomonas sp. strain DSS73 is regulated by components of sugar beet seed exudate via the Gac two-component regulatory system.

Authors:  Birgit Koch; Tommy H Nielsen; Dan Sørensen; Jens Bo Andersen; Carsten Christophersen; Søren Molin; Michael Givskov; Jan Sørensen; Ole Nybroe
Journal:  Appl Environ Microbiol       Date:  2002-09       Impact factor: 4.792

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