Literature DB >> 10021422

Ribozymes, genomics and therapeutics.

J J Rossi1.   

Abstract

Genome-sequencing projects are proceeding at a rapid pace and determining the function of open reading frames is the next great challenge. Ribozymes with site-specific cleaving activity could aid greatly in this process. High-throughput screening methods to identify optimal target sites for ribozyme cleavage will provide tools for functional genomics as well as therapeutic reagents.

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Year:  1999        PMID： 10021422     DOI： 10.1016/S1074-5521(99)80001-5

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  16 in total

1.  Effective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli.

Authors:  P Trang; M Lee; E Nepomuceno; J Kim; H Zhu; F Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

2.  Differential effects of the protein cofactor on the interactions between an RNase P ribozyme and its target mRNA substrate.

Authors:  A W Hsu; A F Kilani; K Liou; J Lee; F Liu
Journal:  Nucleic Acids Res       Date:  2000-08-15       Impact factor: 16.971

3.  Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase.

Authors:  Hiroaki Kawasaki; Kazunari Taira
Journal:  EMBO Rep       Date:  2002-04-18       Impact factor: 8.807

4.  A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries.

Authors:  Hiroaki Kawasaki; Kazunari Taira
Journal:  Nucleic Acids Res       Date:  2002-08-15       Impact factor: 16.971

5.  Impact of DNA gyrase inhibition by antisense ribozymes on rec A in E. coli.

Authors:  Sainath Rao Shilpakala; Malathi Raghunathan
Journal:  Mol Biol Rep       Date:  2008-11-04       Impact factor: 2.316

6.  Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1.

Authors:  Hoshang J Unwalla; Haitang Li; Shi-Yang Li; Danny Abad; John J Rossi
Journal:  Mol Ther       Date:  2008-04-01       Impact factor: 11.454

Review 7.  Biomolecular engineering for nanobio/bionanotechnology.

Authors:  Teruyuki Nagamune
Journal:  Nano Converg       Date:  2017-04-24

8.  Mapping of accessible sites for oligonucleotide hybridization on hepatitis delta virus ribozymes.

Authors:  J Wrzesinski; M Legiewicz; J Ciesiołka
Journal:  Nucleic Acids Res       Date:  2000-04-15       Impact factor: 16.971

9.  Intracellular expression of engineered RNase P ribozymes effectively blocks gene expression and replication of human cytomegalovirus.

Authors:  Kihoon Kim; Sean Umamoto; Phong Trang; Rong Hai; Fenyong Liu
Journal:  RNA       Date:  2004-03       Impact factor: 4.942

10.  Generation of an external guide sequence library for a reverse genetic screen in Caenorhabditis elegans.

Authors:  Qitao Yan; Rui Zhao; Wenlin Zheng; Changxin Yin; Bao Zhang; Wenli Ma
Journal:  BMC Biotechnol       Date:  2009-05-20       Impact factor: 2.563
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