Literature DB >> 10021376

Intracellular signalling: PDK1--a kinase at the hub of things.

C Belham1, S Wu, J Avruch.   

Abstract

Phosphoinositide-dependent kinase 1 (PDK1) is at the hub of many signalling pathways, activating PKB and PKC isoenzymes, as well as p70 S6 kinase and perhaps PKA. PDK1 action is determined by colocalization with substrate and by target site availability, features that may enable it to operate in both resting and stimulated cells.

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Year:  1999        PMID： 10021376     DOI： 10.1016/s0960-9822(99)80058-x

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  62 in total

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