Literature DB >> 10021341

The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.

M Campione1, H Steinbeisser, A Schweickert, K Deissler, F van Bebber, L A Lowe, S Nowotschin, C Viebahn, P Haffter, M R Kuehn, M Blum.   

Abstract

Left-right asymmetry in vertebrates is controlled by activities emanating from the left lateral plate. How these signals get transmitted to the forming organs is not known. A candidate mediator in mouse, frog and zebrafish embryos is the homeobox gene Pitx2. It is asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube. Localized Pitx2 expression continues when these organs undergo asymmetric looping morphogenesis. Ectopic expression of Xnr1 in the right lateral plate induces Pitx2 transcription in Xenopus. Misexpression of Pitx2 affects situs and morphology of organs. These experiments suggest a role for Pitx2 in promoting looping of the linear heart and gut.

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Year:  1999        PMID： 10021341     DOI： 10.1242/dev.126.6.1225

Source DB:  PubMed          Journal:  Development        ISSN： 0950-1991            Impact factor:   6.868


  85 in total

1.  Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling.

Authors:  Qize Wei; Robert S Adelstein
Journal:  Mol Biol Cell       Date:  2002-02       Impact factor: 4.138

2.  Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesis.

Authors:  Joseph P Gormley; Nanette M Nascone-Yoder
Journal:  Dev Genes Evol       Date:  2003-05-23       Impact factor: 0.900

3.  A role for maternal beta-catenin in early mesoderm induction in Xenopus.

Authors:  Anne Schohl; François Fagotto
Journal:  EMBO J       Date:  2003-07-01       Impact factor: 11.598

4.  Parallel genetic origins of pelvic reduction in vertebrates.

Authors:  Michael D Shapiro; Michael A Bell; David M Kingsley
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-31       Impact factor: 11.205

5.  Six3 represses nodal activity to establish early brain asymmetry in zebrafish.

Authors:  Adi Inbal; Seok-Hyung Kim; Jimann Shin; Lilianna Solnica-Krezel
Journal:  Neuron       Date:  2007-08-02       Impact factor: 17.173

Review 6.  Making and breaking symmetry in development, growth and disease.

Authors:  Daniel T Grimes
Journal:  Development       Date:  2019-08-15       Impact factor: 6.868

7.  Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis.

Authors:  Timothy F Plageman; Amanda L Zacharias; Phillip J Gage; Richard A Lang
Journal:  Dev Biol       Date:  2011-06-25       Impact factor: 3.582

8.  Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2.

Authors:  Wenlai Zhou; Lizhu Lin; Arindam Majumdar; Xue Li; Xiaoxue Zhang; Wei Liu; Leah Etheridge; Yunqing Shi; James Martin; Wim Van de Ven; Vesa Kaartinen; Anthony Wynshaw-Boris; Andrew P McMahon; Michael G Rosenfeld; Sylvia M Evans
Journal:  Nat Genet       Date:  2007-09-02       Impact factor: 38.330

9.  Pitx2 regulates gonad morphogenesis.

Authors:  Joaquín Rodríguez-León; Concepción Rodríguez Esteban; Mercè Martí; Belén Santiago-Josefat; Ilir Dubova; Xavier Rubiralta; Juan Carlos Izpisúa Belmonte
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-04       Impact factor: 11.205

10.  Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow.

Authors:  Jonathan Stevens; Alexander Ermakov; Jose Braganca; Helen Hilton; Peter Underhill; Shoumo Bhattacharya; Nigel A Brown; Dominic P Norris
Journal:  BMC Dev Biol       Date:  2010-05-20       Impact factor: 1.978
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