Literature DB >> 1000973

A method of computing drug distribution in plasma using stepwise association constants: clofibrate acid as an illustrative example.

W D Wosilait, P Nagy.   

Abstract

A program is described to compute the distribution of ligand among various complexes of ligand and protein using stepwise association constants. The key input data consists of stepwise association constants and the concentration of macromolecule and various concentrations of ligand. The key output data consists of the concentration of free drug and protein and the concentration of the various complexes.

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Year:  1976        PMID： 1000973     DOI： 10.1016/0010-468x(76)90020-9

Source DB:  PubMed          Journal:  Comput Programs Biomed        ISSN： 0010-468X


  13 in total

1.  Insulin- and leptin-regulated fatty acid uptake plays a key causal role in hepatic steatosis in mice with intact leptin signaling but not in ob/ob or db/db mice.

Authors:  Fengxia Ge; Shengli Zhou; Chunguang Hu; Harrison Lobdell; Paul D Berk
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2010-07-01       Impact factor: 4.052

2.  At physiologic albumin/oleate concentrations oleate uptake by isolated hepatocytes, cardiac myocytes, and adipocytes is a saturable function of the unbound oleate concentration. Uptake kinetics are consistent with the conventional theory.

Authors:  D Sorrentino; R B Robinson; C L Kiang; P D Berk
Journal:  J Clin Invest       Date:  1989-10       Impact factor: 14.808

3.  Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein.

Authors:  W Stremmel
Journal:  J Clin Invest       Date:  1988-12       Impact factor: 14.808

4.  Fatty acid uptake by isolated rat heart myocytes represents a carrier-mediated transport process.

Authors:  W Stremmel
Journal:  J Clin Invest       Date:  1988-03       Impact factor: 14.808

5.  Muscle palmitate uptake and binding are saturable and inhibited by antibodies to FABP(PM).

Authors:  L P Turcotte; J R Swenberger; M Z Tucker; A J Yee; G Trump; J J Luiken; A Bonen
Journal:  Mol Cell Biochem       Date:  2000-07       Impact factor: 3.396

6.  Constitutive expression of a saturable transport system for non-esterified fatty acids in Xenopus laevis oocytes.

Authors:  S L Zhou; D Stump; L Isola; P D Berk
Journal:  Biochem J       Date:  1994-01-15       Impact factor: 3.857

7.  Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization.

Authors:  José L Walewski; Fengxia Ge; Michel Gagner; William B Inabnet; Alfons Pomp; Andrea D Branch; Paul D Berk
Journal:  Obes Surg       Date:  2009-10-29       Impact factor: 4.129

8.  Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut.

Authors:  D Sorrentino; D Stump; B J Potter; R B Robinson; R White; C L Kiang; P D Berk
Journal:  J Clin Invest       Date:  1988-09       Impact factor: 14.808

9.  Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings.

Authors:  Paul D Berk; Shengli Zhou; Michael W Bradbury
Journal:  Trans Am Clin Climatol Assoc       Date:  2005

10.  Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein.

Authors:  W Stremmel; G Strohmeyer; P D Berk
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205
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