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Literature DB >> 100051

Modified peptidoglycan transpeptidase activity in a carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s.

N A Curtis, C Brown, M Boxall, M G Boulton.

Abstract

A carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s was found to possess peptidoglycan transpeptidase activity significantly more resistant to inhibition by benzyl penicillin, ampicillin, carbenicillin, and cephaloridine than that of the parent strain. The mutant was more resistant than the parent strain to all of the beta-lactam antibiotics tested, and 50% inhibition values for these compounds against membrane-bound model transpeptidase activity paralleled this increase. The resistance of the mutant to kanamycin, streptomycin, and chloramphenicol was unchanged.

Entities: Chemical Species

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Year: 1978 PMID： 100051 PMCID： PMC352441 DOI： 10.1128/AAC.14.2.246

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

21 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

2. Mutants of Pseudomonas aeruginosa with impaired -lactamase inducibility and increased sensitivity to -lactam antibiotics.

Authors: A Rosselet; W Zimmermann
Journal: J Gen Microbiol Date: 1973-06

3. Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12.

Authors: B G Spratt
Journal: Proc Natl Acad Sci U S A Date: 1975-08 Impact factor: 11.205

4. Mutant of Pseudomonas aeruginosa 18S that synthesizes type Id beta-lactamase constitutively.

Authors: F Flett; N A Curtis; M H Richmond
Journal: J Bacteriol Date: 1976-09 Impact factor: 3.490

5. Separation of the cytoplasmic and outer membrane of Pseudomonas aeruginosa PAQ.

Authors: B R Booth; N A Curtis
Journal: Biochem Biophys Res Commun Date: 1977-02-07 Impact factor: 3.575

6. Properties of the penicillin-binding proteins of Escherichia coli K12,.

Authors: B G Spratt
Journal: Eur J Biochem Date: 1977-01

7. Indirect method for assessing the penetration of beta-lactamase-nonsusceptible penicillins and cephalosporins in Escherichia coli strains.

Authors: M H Richmond; D C Clark; S Wotton
Journal: Antimicrob Agents Chemother Date: 1976-08 Impact factor: 5.191

8. Mutants of Escherichia coli lacking in highly penicillin-sensitive D-alanine carboxypeptidase activity.

Authors: M Matsuhashi; Y Takagaki; I N Maruyama; S Tamaki; Y Nishimura; H Suzuki; U Ogino; Y Hirota
Journal: Proc Natl Acad Sci U S A Date: 1977-07 Impact factor: 11.205

9. Simultaneous deletion of D-alanine carboxypeptidase IB-C and penicillin-binding component IV in a mutant of Escherichia coli K12.

Authors: M Iwaya; J L Strominger
Journal: Proc Natl Acad Sci U S A Date: 1977-07 Impact factor: 11.205

10. Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.

Authors: C H O'Callaghan; A Morris; S M Kirby; A H Shingler
Journal: Antimicrob Agents Chemother Date: 1972-04 Impact factor: 5.191

6 in total

Review 1. Plasmid-determined resistance to antimicrobial drugs and toxic metal ions in bacteria.

Authors: T J Foster
Journal: Microbiol Rev Date: 1983-09

2. Chromosomal beta-lactamase expression and resistance to beta-lactam antibiotics in Proteus vulgaris and Morganella morganii.

Authors: Y J Yang; D M Livermore
Journal: Antimicrob Agents Chemother Date: 1988-09 Impact factor: 5.191

3. Competition of beta-lactam antibiotics for the penicillin-binding proteins of Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella aerogenes, Proteus rettgeri, and Escherichia coli: comparison with antibacterial activity and effects upon bacterial morphology.

Authors: N A Curtis; D Orr; G W Ross; M G Boulton
Journal: Antimicrob Agents Chemother Date: 1979-09 Impact factor: 5.191